Planes, Trains, and Automobiles

I need to rewatch it but Tommy Boy is a great road trip/buddy movie

BIG with Tom Hanks

Motor, probably best most annoying buddy movie

The movie was funny but no way the best road trip movie. That title goes to "Road Trip"

youtube.com

^^^^^ I don't know about best, But "National Lampoon's Vacation' was one of the funniest road trip movies.

Midnight Run. Best road trip flick. No bullshit, just the truth.

Easy Rider, Thelma & Louise, Sideways, Paper Moon

I think I'd have to go the stoner route with the Harold & Kumar movies and "Jay and Silent Bob Strike Back."

I'll put in my vote for National Lampoon's European Vacation.

I'm with PhantomGeek on this one. Stoner movies for the win!

As for fave movie for lol's, and being able to relate to stuff that happened in movie, "Planes, Trains, and Automobiles" is right up there in my top 3. (Haven't made list, but I know this one would be on it.)